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1

Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors

Su Hui Yang, Daulat Bikram Khadka, Suk Hee Cho, Hye-Kyung Ju, Kwang Youl Lee, Ho Jae Han, Kyung-Tae Lee, Won-Jea Cho

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.53 MB

english, 2011

2

Transduced Tat-glyoxalase protein attenuates streptozotocin-induced diabetes in a mouse model

Kim, Mi Jin, Kim, Dae Won, Lee, Byung Ryong, Shin, Min Jea, Kim, Young Nam, Eom, Seon Ae, Park, Byung-Jae, Cho, Yoon Shin, Han, Kyu Hyung, Park, Jinseu, Hwang, Hyun Sook, Eum, Won Sik, Choi, Soo Young

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 694 KB

english, 2013

3

Topoisomerase inhibitors as anticancer agents: a patent update

Khadka, Daulat B, Cho, Won-Jea

Journal:

Expert Opinion on Therapeutic Patents

Year:

2013

Language:

english

File:

PDF, 2.39 MB

english, 2013

4

Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury

Shin, Min Jea, Kim, Dae Won, Lee, Yeom Pyo, Ahn, Eun Hee, Jo, Hyo Sang, Kim, Duk-Soo, Kwon, Oh-Shin, Kang, Tae-Cheon, Cho, Yong-Jun, Park, Jinseu, Eum, Won Sik, Choi, Soo Young

Journal:

Free Radical Biology and Medicine

Year:

2014

Language:

english

File:

PDF, 11.34 MB

english, 2014

5

The Effects of Increase in Heart Rate on Coronary Flow Reserve and Flow Profiles : A Study with Intracoronary Doppler wire

Kim, Han-Soo, Tahk, Seung-Jea, Shin, Joon-Han, Cho, Yun-Kyung, Kim, Won, Ku, Bon-Kwon, Choi, William Byung-Il

Journal:

Korean Circulation Journal

Year:

1995

File:

PDF, 1.65 MB

1995

6

Prediction of the binding mode of imidacloprid and related compounds to house-fly head acetylcholine receptors using three-dimensional QSAR analysis

Okazawa, Atsushi, Akamatsu, Miki, Ohoka, Akira, Nishiwaki, Hisashi, Cho, Won-Jea, Nakagawa, Yoshiaki, Nishimura, Keiichiro, Ueno, Tamio

Journal:

Pesticide Science

Year:

1998

Language:

english

File:

PDF, 392 KB

english, 1998

7

ChemInform Abstract: A Novel Synthesis of Benzo[c]phenanthridine Skeleton and Biological Evaluation of Isoquinoline Derivatives.

Won-Jea Cho, Myun-Ji Park, Takeshi Imanishi, Byung-Ho Chung

Journal:

Year:

1999

File:

PDF, 31 KB

1999

8

ChemInform Abstract: Convenient Synthesis of 2,3,9,10-Tetraoxygenated Protoberberine Alkaloids and Their 13-Methyl Alkaloids.

Miyoji Hanaoka, Taeko Hirasawa, Won Jea Cho, Shingo Yasuda

Journal:

Year:

2000

File:

PDF, 34 KB

2000

9

ChemInform Abstract: A Convenient Synthesis of 5-Methylbenzo[c]phenanthridin-6(5H)-one.

Won-Jea Cho, In Jong Kim, Sun-Ja Park

Journal:

Year:

2001

File:

PDF, 34 KB

2001

10

Synthesis of New 3-Arylisoquinolinamines: Effect on Topoisomerase I Inhibition and Cytotoxicity.

Won-Jea Cho, Sun Young Min, Thanh Nguyen Le, Tae Sung Kim

Journal:

Year:

2004

Language:

english

File:

PDF, 176 KB

english, 2004

11

A Facile Synthesis of Benzo[c]phenanthridine Alkaloids: Oxynitidine and Oxysanguinarine Using Lithiated Toluamide—Benzonitrile Cycloaddition.

Thanh Nguyen Le, Seong Gyoung Gang, Won-Jea Cho

Journal:

Year:

2004

File:

PDF, 110 KB

2004

12

A Versatile Total Synthesis of Benzo[c]phenanthridine (IX) and Protoberberine (V) Alkaloids Using Lithiated Toluamide—Benzonitrile Cycloaddition.

Thanh Nguyen Le, Seong Gyoung Gang, Won-Jea Cho

Journal:

Year:

2004

File:

PDF, 129 KB

2004

13

Synthesis of Oxychelerythrine Using Lithiated Toluamide-Benzonitrile Cycloaddition.

Thanh Nguyen Le, Won-Jea Cho

Journal:

Year:

2005

File:

PDF, 32 KB

2005

14

ChemInform Abstract: Total Synthesis of 8-Oxypseudopalmatine and 8-Oxypseudoberberine via Ring-Closing Metathesis.

Hue Thi My Van, Su Hui Yang, Daulat Bikram Khadka, Yong-Chul Kim, Won-Jea Cho

Journal:

Year:

2010

File:

PDF, 31 KB

2010

15

ChemInform Abstract: CWJ-081 (I), a Novel 3-Arylisoquinoline Derivative, Induces Apoptosis in Human Leukemia HL-60 Cells Partially Involves Reactive Oxygen Species Through c-Jun NH2-Terminal Kinase Pathway.

So-Jung Won, Kyung-Sook Chung, Yo Sook Ki, Jung-Hye Choi, Won-Jea Cho, Kyung-Tae Lee

Journal:

Year:

2011

File:

PDF, 23 KB

2011

16

ChemInform Abstract: Application of Ring-Closing Metathesis for the Synthesis of Benzo[3,4]azepino[1,2-b]isoquinolin-9-ones.

Hue Thi My Van, Daulat Bikram Khadka, Thanh Nguyen Le, Su Hui Yang, Won-Jea Cho

Journal:

Year:

2012

File:

PDF, 35 KB

2012

17

Synthesis and evaluation of Ketorolac ester prodrugs for transdermal delivery

Hea-Jeong Doh, Won-Jea Cho, Chul-Soon Yong, Han-Gon Choi, Jung Sun Kim, Chi-Ho Lee, Dae-Duk Kim

Journal:

Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 145 KB

english, 2003

18

Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling

Thanh Nguyen Le, Su Hui Yang, Daulat Bikram Khadka, Hue Thi My Van, Suk Hee Cho, Youngjoo Kwon, Eung-Seok Lee, Kyung-Tae Lee, Won-Jea Cho

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 436 KB

english, 2011

19

Synthesis, topoisomerase I inhibition and structure–activity relationship study of 2,4,6-trisubstituted pyridine derivatives

Long-Xuan Zhao, Yoon-Soo Moon, Arjun Basnet, Eun-kyung Kim, Yurngdong Jahng, Jae Gyu Park, Tae Cheon Jeong, Won-Jea Cho, Sang-Un Choi, Chong Ock Lee, Sun-Young Lee, Chong-Soon Lee, Eung-Seok Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 307 KB

english, 2004

20

Ketorolac amide prodrugs for transdermal delivery: stability and in vitro rat skin permeation studies

Bo-Yeon Kim, Hea-Jeong Doh, Thanh Nguyen Le, Won-Jea Cho, Chul-Soon Yong, Han-Gon Choi, Jung Sun Kim, Chi-Ho Lee, Dae-Duk Kim

Journal:

International Journal of Pharmaceutics

Year:

2005

Language:

english

File:

PDF, 239 KB

english, 2005

21

Indeno[1,2-c]isoquinolines as enhancing agents on all-trans retinoic acid-mediated differentiation of human myeloid leukemia cells

Seung Hyun Kim, Sang Mi Oh, Ju Han Song, Daeho Cho, Quynh Manh Le, Suh–Hee Lee, Won-Jea Cho, Tae Sung Kim

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 473 KB

english, 2008

22

Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines

Radha Karki, Pritam Thapa, Mi Jeong Kang, Tae Cheon Jeong, Jung Min Nam, Hye-Lin Kim, Younghwa Na, Won-Jea Cho, Youngjoo Kwon, Eung-Seok Lee

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 663 KB

english, 2010

23

3-Arylisoquinolines as novel topoisomerase I inhibitors

Daulat Bikram Khadka, Won-Jea Cho

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 762 KB

english, 2011

24

Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors

Daulat Bikram Khadka, Quynh Manh Le, Su Hui Yang, Hue Thi My Van, Thanh Nguyen Le, Suk Hee Cho, Youngjoo Kwon, Kyung-Tae Lee, Eung-Seok Lee, Won-Jea Cho

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 501 KB

english, 2011

25

Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors

Won-Jea Cho, Quynh Manh Le, Hue Thi My Van, Kwang Youl Lee, Bok Yun Kang, Eung-Seok Lee, Sang Kook Lee, Youngjoo Kwon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 256 KB

english, 2007

26

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA–topoisomerase I complex

Hue Thi My Van, Quynh Manh Le, Kwang Youl Lee, Eung-Seok Lee, Youngjoo Kwon, Tae Sung Kim, Thanh Nguyen Le, Suh-Hee Lee, Won-Jea Cho

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 277 KB

english, 2007

27

Structural modification of 3-arylisoquinolines to isoindolo[2,1-b]isoquinolinones for the development of novel topoisomerase 1 inhibitors with molecular docking study

Hue Thi My Van, Won-Jea Cho

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 319 KB

english, 2009

28

Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors

Suh-Hee Lee, Hue Thi My Van, Su Hui Yang, Kyung-Tae Lee, Youngjoo Kwon, Won-Jea Cho

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 360 KB

english, 2009

29

2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure–activity relationship, and docking study

Arjun Basnet, Pritam Thapa, Radha Karki, Hoyoung Choi, Jae Hun Choi, Minho Yun, Byeong-Seon Jeong, Yurngdong Jahng, Younghwa Na, Won-Jea Cho, Youngjoo Kwon, Chong-Soon Lee, Eung-Seok Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 670 KB

english, 2010

30

Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agents

Su Hui Yang, Hue Thi My Van, Thanh Nguyen Le, Daulat Bikram Khadka, Suk Hee Cho, Kyung-Tae Lee, Hwa-Jin Chung, Sang Kook Lee, Chang-Ho Ahn, Young Bok Lee, Won-Jea Cho

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 457 KB

english, 2010

31

CWJ-081, a novel 3-arylisoquinoline derivative, induces apoptosis in human leukemia HL-60 cells partially involves reactive oxygen species through c-Jun NH2-terminal kinase pathway

So-Jung Won, Kyung-Sook Chung, Yo Sook Ki, Jung-Hye Choi, Won-Jea Cho, Kyung-Tae Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 578 KB

english, 2010

32

Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship

Uttam Thapa, Pritam Thapa, Radha Karki, Minho Yun, Jae Hun Choi, Yurngdong Jahng, Eunyoung Lee, Kyung-Hwa Jeon, Younghwa Na, Eun-Mi Ha, Won-Jea Cho, Youngjoo Kwon, Eung-Seok Lee

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 507 KB

english, 2011

33

Total synthesis of 8-oxypseudopalmatine and 8-oxypseudoberberine via ring-closing metathesis

Hue Thi My Van, Su Hui Yang, Daulat Bikram Khadka, Yong-Chul Kim, Won-Jea Cho

Journal:

Year:

2009

Language:

english

File:

PDF, 266 KB

english, 2009

34

A facile synthesis of benzo[c]phenanthridine alkaloids: oxynitidine and oxysanguinarine using lithiated toluamide–benzonitrile cycloaddition

Thanh Nguyen Le, Seong Gyoung Gang, Won-Jea Cho

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 267 KB

english, 2004

35

Differential cytotoxic effects of mono-(2-ethylhexyl) phthalate on blastomere-derived embryonic stem cells and differentiating neurons

Chun Kyu Lim, Suel-Kee Kim, Duck Sung Ko, Jea Won Cho, Jin Hyun Jun, Su-Yeon An, Jung Ho Han, Jong-Hoon Kim, Yong-Dal Yoon

Journal:

Year:

2009

Language:

english

File:

PDF, 1.73 MB

english, 2009

36

Asymmetric aldol reaction: A highly erythro-selective aldol reaction between tricarbonyl(o-trimethylsilylbenzaldehyde derivative )-chromium (0) complexes and cyclic silyl enol ethers

Chisato Mukai, Won Jea Cho, In Jong Kim, Masaru Kido, Miyoji Hanaoka

Journal:

Year:

1991

Language:

english

File:

PDF, 1.56 MB

english, 1991

37

A highly erythro selective aldol reaction between chromium-complexed benzaldehyde derivatives and cyclic silyl enol ethers

Chisato Mukai, Won Jea Cho, Miyoji Hanaoka

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 213 KB

english, 1989

38

Tricarbonyl(benzaldehyde)chromium(0) complexes in organic synthesis: A highly stereoselective 1,3-dipolar cycloaddition of chromium(0)-complexed nitrones

Chisato Mukai, Jea Cho Won, Jong Kim In, Miyoji Hanaoka

Journal:

Tetrahedron Letters

Year:

1990

File:

PDF, 152 KB

1990

39

Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-Terpyridine derivatives

Long-Xuan Zhao, Tae Sung Kim, Soo-Hyun Ahn, Tae-Hyung Kim, Eun-kyung Kim, Won-Jea Cho, Heesung Choi, Chong-Soon Lee, Jung-Ae Kim, Tae Cheon Jeong, Ching-jer Chang, Eung-Seok Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 134 KB

english, 2001

40

Synthesis and biological evaluation of 3-arylisoquinolines as antitumor agents

Won-Jea Cho, Myun-Ji Park, Byung-Ho Chung, Chong-Ok Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 247 KB

english, 1998

41

Molecular modeling of 3-arylisoquinoline antitumor agents active against A-549. A comparative molecular field analysis study

Won-Jea Cho, Eui-Ki Kim, Il Yeong Park, Eun Young Jeong, Tae Sung Kim, Thanh Nguyen Le, Dae-Duk Kim, Eung-Seok Lee

Journal:

Bioorganic & Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 630 KB

english, 2002

42

Synthesis and comparative molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives

Won-Jea Cho, Eui-Ki Kim, Myun-Ji Park, Sang-Un Choi, Chong-Ock Lee, Seung Hoon Cheon, Bo-Gil Choi, Byung-Ho Chung

Journal:

Bioorganic & Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 987 KB

english, 1998

43

ACCLIMATION OF PROROCENTRUM MINIMUM (DINOPHYCEAE) TO PROLONGED DARKNESS BY USE OF AN ALTERNATIVE CARBON SOURCE FROM TRIACYLGLYCERIDES AND GALACTOLIPIDS

Kumariah Manoharan, Taek Kyun Lee, Jea Myung Cha, Jeong Ha Kim, Woo Sung Lee, Man Chang, Chul Won Park, Jin Ha Cho

Journal:

Journal of Phycology

Year:

1999

Language:

english

File:

PDF, 170 KB

english, 1999

44

Synthesis and structure-activity relationship studies of 2,3-dihydroimidazo[2,1-a]isoquinoline analogs as antitumor agents

Seung Hoon Cheon, Joon Suck Park, Seon Hee Jeong, Byung-Ho Chung, Bo-Gil Choi, Won-Jea Cho, Boo-Hyon Kang, Chong-Ock Lee

Journal:

Archives of Pharmacal Research

Year:

1997

Language:

english

File:

PDF, 480 KB

english, 1997

45

Synthesis of antineoplaston A10 analogs as potential antitumor agents

Bo-Gil Choi, Ok-Young Kim, Byung-Ho Chung, Won-Jea Cho, Seung-Hoon Cheon, Sang-Un Choi, Chong-Ock Lee

Journal:

Archives of Pharmacal Research

Year:

1998

Language:

english

File:

PDF, 663 KB

english, 1998

46

Synthesis and structure-activity relationship studies of substituted isoquinoline analogs as antitumor agent

Seung Hoon Cheon, Joon Suck Park, Byung-Ho Chung, Bo-Gil Choi, Won-Jea Cho, Sang-Un Choi, Chong-Ock Lee

Journal:

Archives of Pharmacal Research

Year:

1998

Language:

english

File:

PDF, 480 KB

english, 1998

47

Structure-activity relationship studies of isoquinolinone type anticancer agent

Seung Hoon Cheon, Joon Suck Park, Joon Yeol Lee, You Na Lee, Hyo Yi, Byung-Ho Chung, Bo-Gil Choi, Won-Jea Cho, Sang-Un Choi, Chong-Ock Lee

Journal:

Archives of Pharmacal Research

Year:

2001

Language:

english

File:

PDF, 444 KB

english, 2001

48

Synthesis of sesquiterpene derivatives as potential antitumor agents; Elemane derivatives

Bo Gil Choi, Eun Yee Kwak, Byung Ho Chung, Won Jea Cho, Seung Hoon Cheon

Journal:

Archives of Pharmacal Research

Year:

1999

Language:

english

File:

PDF, 300 KB

english, 1999

49

Synthesis and antitumor activity of 3-arylisoquinoline derivatives

Won-Jea Cho, Su-Jeong Yoo, Myun-Ji Park, Byung-Ho Chung, Chong-Ock Lee

Journal:

Archives of Pharmacal Research

Year:

1997

Language:

english

File:

PDF, 422 KB

english, 1997

50

Studies on the synthesis andin vitroantitumor activity of the isoquinolone derivatives

Seung Hoon Cheon, Joon Yeol Lee, Byung-Ho Chung, Bo-Gil Choi, Won-Jea Cho, Tae Sung Kim

Journal:

Archives of Pharmacal Research

Year:

1999

Language:

english

File:

PDF, 438 KB

english, 1999

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